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Properties and catalytic mechanism of -glutamyltranspeptidase from NX-2

WANG Qian, YAO Zhong, XUN Zhijing, XU Xiaoying, XU Hong, WEI Ping

《化学科学与工程前沿（英文）》 2008年 第2卷 第4期   页码 456-461 doi: 10.1007/s11705-008-0075-3

摘要： Since -glutamyltranspeptidase (GGT) especially catalyses the transfer of the -glutamyl moiety to a variety of amino acids and short peptides, GGT has important practical value for enzymatic synthesis of -glutamyl compounds. In this paper, the GGT produced from NX-2 was purified by a combination of ammonium sulfate fractionation and ion exchange chromatography, and the properties of purified GGT were investigated. At the conditions of pH 10.0, D-glutamine (D-Gln)/L-tryptophan (L-Trp) with a molar ratio of 5 : 7, a temperature 40°C and a reaction time of 4 h, a higher conversion rate of 42% was obtained. According to the time course, the catalytic mechanism of enzymatic synthesis of -D-glutamyl-L-tryptophan (-D-Gln-L-Trp) was discussed. It was demonstrated that the GGT can catalyze not only the reaction of transpeptidation, but also the irreversible hydrolysis of the products which results in the decrease of the yield of the products. The affinity parameter of GGT to D-Gln (Km) was 5.08 mmol·L and the maximum reaction rate of transpeptidation () was determined as 0.034 mmol·min·L, while the affinity parameter of GGT to -D-Gln-L-Trp (’) was 2.267 mmol·L, and the maximum reaction rate of hydrolysis (’) was 0.012 mmol·min·L.

关键词： catalytic mechanism     mmol·min·L     D-glutamine     affinity parameter     important practical    

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The development trend and practical innovation of smart cities under the integration of new technologies

Xiaohong CHEN

《工程管理前沿（英文）》 2019年 第6卷 第4期   页码 485-502 doi: 10.1007/s42524-019-0057-9

摘要： Smart cities have rapidly developed in the context of the integration of new digital technologies such as big data, Internet of Things, artificial intelligence, blockchains, and virtual reality. These cities have conducted practical innovations and typical cases in many sectors, such as in government, transportation, environmental protection, energy, medical care, and logistics, and have produced many social, economic, and ecological benefits. However, there are still some problems that continue to hinder the construction of smart cities. This paper examines such problems in depth and proposes some relevant countermeasures and suggestions.

关键词： new technology integration     smart city     big data     practical innovation    

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Flocculation behaviors of a novel papermaking sludge-based flocculant in practical printing and dyeing

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1390-x

摘要：

•PSBF performed better than PAC and PAM in CODCr removals.

关键词： Practical wastewater treatment     Commercial coagulant/flocculant     Secondary coagulation-flocculation process     Chemical oxygen demand     Coagulation-flocculation mechanism    

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P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

《能源前沿（英文）》 2023年 第17卷 第2期   页码 189-197 doi: 10.1007/s11708-023-0873-9

摘要： Peer-to-peer (P2P) energy trading is an emerging energy supply paradigm where customers with distributed energy resources (DERs) are allowed to directly trade and share electricity with each other. P2P energy trading can facilitate local power and energy balance, thus being a potential way to manage the rapidly increasing number of DERs in net zero transition. It is of great importance to explore P2P energy trading via public power networks, to which most DERs are connected. Despite the extensive research on P2P energy trading, there has been little large-scale commercial deployment in practice across the world. In this paper, the practical challenges of conducting P2P energy trading via public power networks are identified and presented, based on the analysis of a practical Local Virtual Private Networks (LVPNs) case in North Wales, UK. The ongoing efforts and emerging solutions to tackling the challenges are then summarized and critically reviewed. Finally, the way forward for facilitating P2P energy trading via public power networks is proposed.

关键词： distribution network     local virtual private network     network charges     peer-to-peer (P2P) energy trading     practical implementation.    

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A reliable and practical reference objective for the deviation diagnosis of energy system parameters

Liping LI, Zheng LI,

《能源前沿（英文）》 2009年 第3卷 第4期   页码 440-445 doi: 10.1007/s11708-009-0051-8

摘要： The core objective to optimize a complex energy system is to set the reference target to guide the parameter adjustment of system operation. In this paper, a new case-based approach is proposed based on an online performance assessment program and its long-term operation data for a large power unit. The online model of a coal-fired power unit’s performance assessment is demonstrated, and the distribution pattern of the performance index is revealed by statistical analysis of the abundant data. The fundamental issues (representation of the similarity of two thermal processes, similarity measure, etc.) are tackled. The key sections and key parameters for the completion of similarity determination are proposed, which are essential to realize a case-based strategy. A full-scope simulator of power unit is used to test the availability of the method. The advantage of the case-based approach is the integrality of information over other methods.

关键词： energy system     case-based     optimization     power unit operation     performance    

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Innovation, practical benefits and prospects for the future development of automatic milking systems

Hongzhe JIANG,Wei WANG,Chunyang LI,Wei WANG

《农业科学与工程前沿（英文）》 2017年 第4卷 第1期   页码 37-47 doi: 10.15302/J-FASE-2016117

摘要： Automatic milking systems (AMS) were designed to replace existing, labor-intensive machine milking and are an area of rapid development in modern dairy farming. The popularity of AMS lies in the convenience of management, decreasing workloads and the consistency of milking compared with non-automated machine milking. Nevertheless, this innovation has not been reviewed comprehensively and the practical benefits of AMS are still unclear. This review gives a brief overview of the historical development of milking machines and the workflow process of state-of-the-art AMS. In addition, a series of comparisons between AMS and current milking machines are made with respect to labor savings, quality parameters, udder health, herd behavior and mastitis detection and are summarized on the basis of relevant studies to show the benefits of the technological changes achieved by AMS. Finally, this review addresses several deficiencies in the technology and procedures of current AMS that need to be improved and also assesses recent advances in milking techniques with a particular focus on their potential for application in AMS.

关键词： automatic milking systems (AMS)     innovation     milking machine     practical effect     future prospects    

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Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 261-274 doi: 10.1007/s11684-015-0406-y

摘要：

Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.

关键词： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

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Elements’ important ranking of China drug safety management system: applying the non-structural

Xiaoping ZHENG, Xiaocui WANG, Tingkuan ZHONG,

《化学科学与工程前沿（英文）》 2010年 第4卷 第3期   页码 290-299 doi: 10.1007/s11705-009-0283-5

摘要： Drug safety management is an important issue in China drug management system and attracts great attentions from the whole society. In order to reduce drug incident, this study discusses some important elements associated with China drug safety management system and analyzes the data collected by questionnaires. Besides, a methodology for rating the important elements is described and applied. The non-structural fuzzy group decision method not only considers the insufficient precise information but also combines the opinions of different kinds of respondents in China’s four municipalities. The results indicate that the sample systems are the most important in these important elements, and the order of importance is sampling systems, licensing systems, traceability systems, transaction models, pharmacovigilance and emergence management. This study not only points out the important ranking of the pivotal elements in China drug safety management but also gives some specific proposals about how to enhance drug safety management in China.

关键词： management system     different     management     important ranking     non-structural fuzzy    

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Presentation of machine learning methods to determine the most important factors affecting road traffic

Hamid MIRZAHOSSEIN; Milad SASHURPOUR; Seyed Mohsen HOSSEINIAN; Vahid Najafi Moghaddam GILANI

《结构与土木工程前沿（英文）》 2022年 第16卷 第5期   页码 657-666 doi: 10.1007/s11709-022-0827-z

摘要： The purpose of this research was to develop statistical and intelligent models for predicting the severity of road traffic accidents (RTAs) on rural roads. Multiple Logistic Regression (MLR) was used to predict the likelihood of RTAs. For more accurate prediction, Multi-Layer Perceptron (MLP) and Radius Basis Function (RBF) neural networks were applied. Results indicated that in MLR, the model obtained from the backward method with the correct percent of 84.7% and R2 value of 0.893 was the best method for predicting the likelihood of RTAs. Also, MLR showed that the variables of not paying attention to the front not paying attention to the frontroad ahead, followed byand then vehicle-motorcycle/bike accidents were the greatest problems. Among the models, MLP had a better performance, so that the prediction accuracy of MLR, MLP, and RBF were 84.7%, 96.7%, and 92.1%, respectively. MLP model, due to higher accuracy, showed that the variable of reason of accident had the highest effect on the prediction of accidents, and considering MLR results, the variables of not paying attention to the front and then vehicle-motorcycle/bike accidents had the most influence on the occurrence of accidents. Therefore, motorcyclists and cyclists are more prone to accidents, and appropriate solutions should be adopted to enhance their safety.

关键词： safety     rural accidents     multiple logistic regression     artificial neural networks    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 877-894 doi: 10.1007/s11709-021-0756-2

摘要： Many bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic load model. Measured multi-lane traffic data generally exhibit significant lane disparities in traffic loads over multiple lanes. However, these disparities are not considered in current specifications. To address this drawback, a multi-coefficient MLF model was developed based on an improved probabilistic statistical approach that considers the presence of multiple trucks. The proposed MLF model and approach were calibrated and demonstrated through an example site. The model sensitivity analysis demonstrated the significant influence of lane disparity of truck traffic volume and truck weight distribution on the MLF. Using the proposed approach, the experimental site study yielded MLFs comparable with those directly calculated using traffic load effects. The exclusion of overloaded trucks caused the proposed approach, existing design specifications, and conventional approach of ignoring lane load disparity to generate comparable MLFs, while the MLFs based on the proposed approach were the most comprehensive. The inclusion of overloaded trucks caused the conventional approach and design specifications to overestimate the MLFs significantly. Finally, the benefits of the research results to bridge practitioners were discussed.

关键词： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion data    

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Genomic regions under selection for important traits in domestic horse breeds

Xuexue LIU, Yuehui MA, Lin JIANG

《农业科学与工程前沿（英文）》 2017年 第4卷 第3期   页码 289-294 doi: 10.15302/J-FASE-2017155

摘要： Horses were domesticated 5500 years ago, thousands of years later than other domestic animals; however, in this relatively short period, domestic horses have had a great impact on human history by accelerating civilization, revolutionizing warfare and advancing agricultural production. Modern breeding using marker-assisted selection has greatly accelerated breeding progress. Therefore, identification of genetic markers underlying the traits of interest in domestic horses is the basis for the modern breeding system. In this review, we present an overview of genetic mapping studies and genome wide analyses to identify the genomic regions targeted by positive selection for four important aspects of horses, coat color, racing performance, gait and height at withers. The locus, for example, has been shown to be the main gene responsible for chestnut color, and the locus has been shown to control the muscle fiber growth in racing breeds. The missense mutation in is the causal mutation for the alternate gaits in horses. Height at withers, a quantitative trait, was mapped to four major loci (3:105547002, 6:81481064, 9:75550059 and 11:232597 32) that can explain 83% of the height variations in domestic horses.

关键词： horse     coat color     racing performance     gait     height    

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Recent advances in understanding genetic variants associated with economically important traits in sheep

Song-Song XU, Meng-Hua LI

《农业科学与工程前沿（英文）》 2017年 第4卷 第3期   页码 279-288 doi: 10.15302/J-FASE-2017151

摘要： Sheep are one of the most economically important domesticated animals for human society. However, genetic improvements for the key traits associated with meat, growth, milk, wool, reproduction, horns and tails progress slowly using conventional crossbreeding methods. With the development and utilization of high-throughput screening technologies over the last decade, a list of functional genes and genetic variants associated with these traits has been identified. This review covers recent genome-wide studies on sheep productive traits using high-throughput screening technologies, including those based on single-nucleotide polymorphisms and copy number variants at the whole-genome level (e.g., genome-wide association studies), transcriptome and DNA methylation sequences. Additionally, comprehensive information on functional genes and genetic variants associated with economically important traits in sheep is provided.

关键词： sheep     high-throughput screening     productive traits     genome-wide studies    

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知识发现领域中当今面临的五类重大问题

杨炳儒

《中国工程科学》 2009年 第11卷 第4期   页码 76-83

摘要：

系统地总结与提出知识发现(KD)领域中当今面临的五类重大问题，它们是KD中的两大核心问题、两大猜想问题、主流发展中富有挑战性的问题、应用研究中的相关领域重大问题以及KD技术标准的制定问题，并给出其部分成果或具体分析。这五类问题密切相关，对它们的研究必将KD推向新的发展阶段,并在该领域内外产生深刻的影响。

关键词： KD核心问题     KD猜想     KD挑战性问题     蛋白质二级结构预测     KD技术标准    

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Confined masonry as practical seismic construction alternative–the experience from the 2014 Cephalonia

Fillitsa KARANTONI, Stavroula PANTAZOPOULOU, Athanasios GANAS

《结构与土木工程前沿（英文）》 2018年 第12卷 第3期   页码 270-290 doi: 10.1007/s11709-017-0390-1

摘要：

During August 1953 three strong earthquakes of magnitude ranging from 6.3 to 7.2 shook the Ionian Island of Cephalonia (Kefalonia), Greece, and destroyed almost the entire building stock of the Island which consisted primarily of traditional unreinforced masonry (URM) houses. The authorities went on to restructuring of the building stock, using a structural system that is most like what is known today as confined masonry. They designed about 14 types of one- to two-storey buildings providing the engineers with detailed construction plans. These buildings are known as “Arogi” buildings (Arogi in Greek meaning Aid). On the 24th of January and 3rd of February 2014, two earthquakes of magnitude 6.1 and 6.0 struck the island, causing significant soil damages, developing excessively high ground accelerations. Surprisingly, no damage was reported in the “Arogi” buildings. The seismic behavior of the buildings is examined by FEM linear analysis and it is compared to that of URM structures. Computed results illustrate that the displacements of identical URM buildings would be about twice the magnitudes observed in the corresponding “Arogi” ones, with the implication that the earthquake sequence of 2014 would have caused critical damage should the type of structure be of the URM type. Furthermore, it is illustrated that this low cost alternative method of construction is a very effective means of producing earthquake resilient structures, whereas further reduction of seismic displacement may be achieved in the order of 50% with commensurate effects on damage potential, when reinforced slabs are used to replace the timber roofs.

关键词： Cephalonia     confined masonry     comparative FEM analysis     unreinforced masonry     seismic damage    

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Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

《医学前沿（英文）》 2022年 第16卷 第3期   页码 389-402 doi: 10.1007/s11684-021-0856-3

摘要： Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia (SCAP). We prospectively enrolled consecutive SCAP patients admitted to ICU. Bronchoscopy was performed at bedside within 48 h of ICU admission, and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid. The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy. Sixty-seven patients were included. Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota (R2=0.033; P=0.018), followed by acute kidney injury (AKI; R2=0.032; P=0.011) and plasma MIP-1β level (R2=0.027; P=0.044). Random forest identified that the families Prevotellaceae, Moraxellaceae, and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results. Multivariable Cox regression showed that the increase in α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements. The positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients’ lung microbiota composition on ICU admission. The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

关键词： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale     Prevotellaceae    

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标题 作者 时间 类型 操作

Properties and catalytic mechanism of -glutamyltranspeptidase from NX-2

WANG Qian, YAO Zhong, XUN Zhijing, XU Xiaoying, XU Hong, WEI Ping

期刊论文

The development trend and practical innovation of smart cities under the integration of new technologies

Xiaohong CHEN

期刊论文

Flocculation behaviors of a novel papermaking sludge-based flocculant in practical printing and dyeing

期刊论文

P2P energy trading via public power networks: Practical challenges, emerging solutions, and the way forward

期刊论文

A reliable and practical reference objective for the deviation diagnosis of energy system parameters

Liping LI, Zheng LI,

期刊论文

Innovation, practical benefits and prospects for the future development of automatic milking systems

Hongzhe JIANG,Wei WANG,Chunyang LI,Wei WANG

期刊论文

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

null

期刊论文

Elements’ important ranking of China drug safety management system: applying the non-structural

Xiaoping ZHENG, Xiaocui WANG, Tingkuan ZHONG,

期刊论文

Presentation of machine learning methods to determine the most important factors affecting road traffic

Hamid MIRZAHOSSEIN; Milad SASHURPOUR; Seyed Mohsen HOSSEINIAN; Vahid Najafi Moghaddam GILANI

期刊论文

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

期刊论文

Genomic regions under selection for important traits in domestic horse breeds

Xuexue LIU, Yuehui MA, Lin JIANG

期刊论文

Recent advances in understanding genetic variants associated with economically important traits in sheep

Song-Song XU, Meng-Hua LI

期刊论文

知识发现领域中当今面临的五类重大问题

杨炳儒

期刊论文

Confined masonry as practical seismic construction alternative–the experience from the 2014 Cephalonia

Fillitsa KARANTONI, Stavroula PANTAZOPOULOU, Athanasios GANAS

期刊论文

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

期刊论文